On March 25, 1999, about 0850 eastern daylight time, a Beech 23, N9249S, registered to an individual impacted with a tree during climbout near Apex, North Carolina. Visual meteorological conditions prevailed at the time, and no flight plan was filed for the 14 CFR Part 91 personal flight. The airplane sustained substantial damage. The private-rated pilot reported no injuries, and two passengers reported serious injuries. The flight had just departed en route to Orangeburg, South Carolina, and was originating at the time. The pilot had taxied the airplane to runway 09, and planned a short field takeoff. He ran the engine to full power, released the foot brakes, applied full right rudder, in anticipation of the airplane yawing to the left, and applied back pressure on the yoke. As the nose rotated, the stall warning horn sounded and the airplane drifted to the right. The pilot applied left aileron, but never released the right rudder pedal. The airplane continued to drift right until it struck a tree, turning the airplane hard to the right, and striking the next tree with the spinner of the propeller. The airplane came to rest opposite the direction of takeoff, against a cluster of trees, supported by the left wing.