On November 3, 1995, about 1647 Alaska standard time, a wheel equipped Cessna 207, N88BC, collided with terrain during takeoff at Toksook Bay, Alaska. The airplane was being operated as flight number 1216 on a visual flight rules (VFR) cross-country scheduled passenger flight under Title 14 CFR Part 135 when the accident occurred. The airplane, operated by Mark Air Express, Anchorage, Alaska, sustained substantial damage. The certificated commercial pilot and 6 passengers, were not injured. Visual meteorological conditions prevailed. VFR company flight following procedures were in effect. The operator reported that the pilot was departing runway 33 for a flight to Bethel, Alaska. The pilot and other pilot witnesses reported that snow showers were present in the area. The pilot arrived at Toksook Bay about 1609. She loaded the passengers and waited on the ground for conditions to improve. The pilot indicated that prior to departure, she removed snow from the windshield and the leading edge of the wing. During the takeoff roll, the airplane did not become airborne until the pilot added full flaps. The airplane lifted off but could not climb out of ground effect. A small hill was ahead of the pilot and she began to retract the flaps. The airplane collided with rising terrain about 1/4 mile north of the departure end of the runway. The airplane received damage to the left main landing gear, left wing, nose gear and propeller. A pilot/witness indicated that after the accident, he walked to the accident site and observed snow on the upper surface of the wings. The Alaska airport/facility directory supplement indicates in part:..."Runway uneven grade, deep dip 800 feet from threshold of runway 33. Runway 15-33 slopes down 2 percent to the south end"...