During the take off ground run, witnesses reported that the engine sounded normal, however, the airplane remained on the runway for an unusual length of time. When the airplane finally lifted off near the end of the runway, the angle of attack increased above normal. The airplane continued to climb in this attitude, with the wings wagging up and down. The airplane attained an altitude of approximately 100 to 200 feet when the right wing and nose dropped toward the ground. The airplane collided with the ground approximately one half mile north of the airport in a nose down, right wing low attitude. A post crash fire ignited and consumed the airplane. During a post crash engine teardown, it was found that the number six cylinder could not hold compression. Further teardown revealed a section of the cylinder around the exhaust seal was missing. Metallurgical examination revealed that the damage most likely occurred as a result of extremely lean operations which led to detonation. The pilot had recently purchased the airplane, which was equipped with a turbo charger, and was taught to lean the mixture for take off. The operator's manual states for take off to have the mixture full rich.