The pilot stated she felt the twin engined tailwheel cargo airplane yaw to the right during takeoff. The pilot stated she applied left rudder and set differential power to correct for the perceived right hand crosswind. As the airplane lifted off, it made a sharp right turn and performed left and right banks leveling off prior to colliding with the ground. The airplane slid through security fences and a fuel supply depot before stopping. The newspaper bundle cargo moved from the two forward bays to the aft end of the cargo compartment. The newspapers were covered with plastic wrapper. The cargo compartment floor was slippery when walked upon and had traces of snow on it. According to the pilot the cargo was covered by a cargo net secured at the forward end but not at the aft end. Two cargo straps were crisscrossed over the net and secured at the aft end of the cargo load. The left throttle was found in the full forward position. The right throttle was found one inch aft of the full forward position.