THE VFR PILOT DEPARTED BOONE, NC, AND CONTACTED TRI APCH STATING THEY WERE 2 DME FROM THE HOLSTON VOR, LEVEL AT 6,500 FT EN ROUTE TO THE HAZARD VOR. THE PLT LATER REQUESTED A DESCENT DOWN TO 5,500 FT. THE PLT REQUESTED A FREQ CHANGE AND NO FURTHER COMMUNICATIONS WERE MADE. THE ACFT CONTACTED A 4,400 FT MOUNTAIN AT AN ELEVATION OF 4,162 FT. THE ACFT TRAVELED THROUGH TREES PRIOR TO COMING TO REST IN A 45 DEG NOSE DOWN ATTITUDE. THE WX DATA LISTED IN THIS REPORT WAS RECORDED AT A REPORTING FACILITY 28 NM FROM THE ACCIDENT SITE. A POLICE OFFICER AND A FOREST SERVICE RANGER STATED THE LOCAL WX CONDITIONS WERE LOW CEILINGS, FOG AND DRIZZLE DURING THE DAY OF THE ACCIDENT. CAP LOCATED THE WRECKAGE 2 DAYS AFTER THE ACCIDENT. POST ACCIDENT INSPECTION FAILED TO REVEAL ANY MECHANICAL FAILURE/MALFUNCTION OF THE AIRFRAM, FLT CONTROLS, OR ENGINE.