On October 13, 2006, about 1512 Alaska daylight time, a wheel-equipped Cessna 207 airplane, N7336U, sustained substantial damage when it collided with the edge of a river embankment during the landing approach at the Tuntutuliak Airport, Tuntutuliak, Alaska. The airplane was being operated as a visual flight rules (VFR) cross-country nonscheduled cargo flight under Title 14, CFR Part 135, when the accident occurred. The airplane was operated by Flight Alaska Inc., d.b.a. Yute Air Alaska, Anchorage, Alaska. The commercial certificated pilot, the sole occupant, received minor injuries. Instrument meteorological conditions prevailed in the area of the accident. VFR company flight following procedures were in effect. The flight originated at the Bethel Airport, Bethel, Alaska, about 1443. During a telephone conversation with the National Transportation Safety Board (NTSB) investigator-in-charge (IIC), on October 16, the director of operations for the operator reported that he interviewed several witnesses to the accident, and learned that the pilot was attempting to land on runway 20 at Tuntutuliak. The gravel surface runway is 1,772 long and 28 feet wide. The approach end of the runway is located at the edge of a river. The director of operations said the weather conditions in the area had been good VFR, but as the pilot was attempting to land, rain and mist moved over the area, reducing the visibility to about 1/4 mile. The airplane collided with the river embankment as the pilot was on his fourth landing attempt. The airplane received structural damage to the landing gear, fuselage and wings, and came to rest about 40 degrees to the left of the runway. The director of operations indicated that within 30 minutes of the accident, the weather conditions were once again VFR. A Federal Aviation Administration (FAA) inspector from the Anchorage Flight Standards District Office (FSDO) interviewed the pilot by telephone. The inspector indicated that the pilot's assessment of the weather conditions was a 500 foot ceiling and 2 miles of visibility. The pilot reported that he made 3 passes over the runway before attempting to land. On the last landing approach, while maintaining 80 knots airspeed, the pilot said the nose of the airplane dropped, he applied full power and tried to raise the nose, but the airplane collided with the river bank.