On June 10, 2017, about 1320 central daylight time, a Hughes 269C helicopter, N7482F, was substantially damaged during a ground resonance event at the Vicksburg Tallulah Regional Airport (TVR), Tallulah, Louisiana. The pilot was not injured. The helicopter was registered to Wade and Son, Inc., and operated by the pilot as a 14 Code of Federal Regulations Part 91 instructional flight. Day visual meteorological conditions prevailed at the accident site. The flight was not operated on a flight plan. The local flight was originating at the time of the accident.The pilot reported that the cyclic trim was not re-centered before takeoff as noted on the checklist. Instead, it remained at a nearly full forward position from the previous flight. The engine start and run-up were normal. At full power for takeoff, the helicopter began to vibrate. The pilot "rolled the throttle off" and lowered the collective; however, the vibrations became worse and the helicopter "began to destroy itself." He noted that if the cyclic had been centered, the vibrations would have stopped. However, with the trim full forward, the rotor blades began hitting the stops causing the vibrations. The pilot added that there were no malfunctions or failures with the helicopter before the accident. The helicopter came to rest upright on the airport ramp. A postaccident examination revealed that the engine had partially separated from the airframe and the main rotor gearbox had separated from the rear bulkhead. The landing skid dampers appeared intact, with no visible damage or fluid leakage.