HISTORY OF FLIGHTOn December 30, 2018, about 1948 eastern standard time, a Piper PA-23 airplane, N2146P, impacted trees and terrain shortly after takeoff from Beaver Island Airport (SJX), Beaver Island, Michigan. The pilot sustained fatal injuries. The airplane was destroyed. The airplane was registered to and operated by the pilot as a Title 14 Code of Federal Regulations Part 91 personal flight. Dark night visual meteorological conditions (VMC) prevailed. The flight was originating at the time of the accident and was destined for the Fitch H. Beach Airport (FPK), Charlotte, Michigan. Due to the government furlough, neither the National Transportation Safety Board, nor the Federal Aviation Administration responded to the accident site. The on-scene documentation for this accident was conducted by the Charlevoix County Sheriff's Department. A witness reported hearing the airplane for about 10 minutes before the sound of the engines increased dramatically. He added, "it was very loud." After taking off, the airplane seemed to turn to the right (north). Shortly afterward, the sound changed to a lower pitch similar to when a pilot adjusts the pitch of the propellers; then it went silent; although, he did not recall hearing the impact. A second witness noted that the airplane was "real loud." She subsequently drove past the airport and observed the airplane which appeared to be taking off to the west. Nothing seemed unusual during the time she saw it. She did not witness the accident and only heard about it later that evening. A third witness reported hearing the "distinct sound" of a twin-engine airplane. He noted that it was "plenty loud" and that the engines didn't seem to be having any difficulties. Shortly afterward, the sound of the engines abruptly "went quiet," after which he heard the airplane impacting the trees. The airplane impacted a wooded area about 1/3 mile north-northeast of the departure end of the runway. The impact path was oriented toward the north-northeast and was about 115 feet long. PERSONNEL INFORMATIONThe pilot's logbook was not available. On his most recent application for a Federal Aviation Administration (FAA) medical certificate, the pilot reported a total flight time of 5,468 hours, with 52.2 hours within the preceding 6 months. He held an instrument rating; however, his recent instrument experience could not be determined. In addition, his recent night flight experience was unknown. The pilot's family stated that he was familiar with the route of flight, having completed the trip between SJX and FPK at least twice per month. AIRCRAFT INFORMATIONAt the time of the most recent annual inspection on September 27, 2018, the airframe had accumulated 8,809 hours total time. The left and right engines had accumulated 4,223 hours and 2,333 hours total time, respectively. Both engines had accumulated 105 hours since overhaul. The airplane was equipped and had current inspections for flight under instrument flight rules. METEOROLOGICAL INFORMATIONBoth witnesses recalled that there was no precipitation at the time of the accident. One witness added that it was "very dark." Sunset occurred at 1707 on the day of the accident and civil twilight ended at 1741. The moon had set at 1328 and did not rise again until 0249 the following day. AIRPORT INFORMATIONAt the time of the most recent annual inspection on September 27, 2018, the airframe had accumulated 8,809 hours total time. The left and right engines had accumulated 4,223 hours and 2,333 hours total time, respectively. Both engines had accumulated 105 hours since overhaul. The airplane was equipped and had current inspections for flight under instrument flight rules. WRECKAGE AND IMPACT INFORMATIONThe fuselage was fragmented consistent with impact forces. The wings were separated from the fuselage at the roots and both engines had separated from their respective wing pylons. The horizontal stabilizers remained attached to the aft fuselage section; however, the vertical stabilizer was separated at the root. The fragmented debris was located along the impact path from the vicinity of the initial tree strike to the main wreckage. A post-recovery examination did not reveal any anomalies consistent with a preimpact failure or malfunction. No evidence of an in-flight structural failure was observed. ADDITIONAL INFORMATIONControllable-Pitch Propeller The Federal Aviation Administration (FAA) Airplane Flying Handbook noted that for airplanes equipped with constant speed propellers, the power output of the engine(s) is reduced when climbing out after takeoff by decreasing the manifold pressure (throttle control) and reducing the engine speed by increasing the propeller blade angle (prop control). Spatial Disorientation The FAA Civil Aeromedical Institute's publication, "Introduction to Aviation Physiology," defines spatial disorientation as a loss of proper bearings or a state of mental confusion as to position, location, or movement relative to the position of the earth. Factors contributing to spatial disorientation include changes in acceleration, flight in instrument meteorological conditions (IMC), frequent transfer between VMC and IMC, and unperceived changes in aircraft attitude. The FAA Airplane Flying Handbook describes some hazards associated with flying when the ground or horizon are obscured. The handbook states, in part: "The vestibular sense (motion sensing by the inner ear) in particular tends to confuse the pilot. Because of inertia, the sensory areas of the inner ear cannot detect slight changes in the attitude of the airplane, nor can they accurately sense attitude changes that occur at a uniform rate over a period of time. On the other hand, false sensations are often generated; leading the pilot to believe the attitude of the airplane has changed when in fact, it has not. These false sensations result in the pilot experiencing spatial disorientation." MEDICAL AND PATHOLOGICAL INFORMATIONAn autopsy, performed on behalf of the Charlevoix County Medical Examiner, Boyne City, Michigan, attributed the pilot's death to multiple blunt injuries sustained in the accident. Toxicology testing performed by the FAA Forensic Sciences Laboratory identified atorvastatin in liver tissue. Atorvastatin is commonly prescribed to lower blood cholesterol/triglyceride levels and is not considered to be impairing.