On May 4, 2019, about 0945 Pacific daylight time, a Bell 206B helicopter, N49643, was destroyed when it was involved in an accident near Oxnard, California. The pilot was seriously injured. The helicopter was operated as a Title 14 Code of Federal Regulations Part 133 aerial application flight. The operator reported that this was the helicopters third flight of the day. However, this was the first paint material load of the day. As the pilot made his third pass over the greenhouses, he noticed that he was using more left cyclic to maintain level flight. He continued to spray in attempt to correct any load imbalances, however, the helicopter continued to lean further to the right. The pilot maneuvered away from the greenhouses. The helicopter’s right turn continued to increase until it impacted the ground at about a 45-degree bank. A post impact fire ensued and completely consumed the helicopter. The operator further reported that the helicopter was equipped with 2, 60-gallon mixture tanks mounted on each side of the aircraft. The tanks were connected through a transfer equalizing tube which fed a centrally located electric pump. The pump then sent the wash through the spray booms. The operator mentioned that they believe one of the mixture tanks stopped transferring, which would cause the helicopter to be imbalanced. Postaccident examination of the helicopter did not reveal any anomalies with the helicopter, however, it was destroyed, and mostly consumed by impact and fire related damage.