On March 9, 2025, about 1530 eastern daylight time, a Beech A36TC, N347M, was substantially damaged when it was involved in an accident near Lititz, Pennsylvania. The pilot and one passenger were seriously injured, and the three other passengers sustained minor injuries. The airplane was operated as a Title 14 Code of Federal Regulations Part 91 personal flight. According to the pilot, during takeoff, he heard a loud “pop” and was unsure what it was. He reduced engine power by pulling the throttle back, then realized the cabin door had opened. He thought that he subsequently pushed the throttle forward but was not sure. He noticed that the airplane’s airspeed was not increasing, and he immediately looked for a place to land. He was unable to recall anything that happened after that point. According to the passenger who was seated in the middle row seat behind the pilot, as soon as the airplane left the ground, the front door opened. The pilot contacted the air traffic control tower and requested to return, and the right-front-seat passenger held the door closed. The airplane began to turn left and started “shaking” before it crashed. A security camera located at an apartment complex across the street from the airport captured the airplane departing the runway and turning left. As the airplane lost altitude in the turn, the wings were rocking back and forth, and the tail was low. The airplane impacted the ground and continued into a parking lot, striking several cars. A postcrash fire consumed most of the airplane, including the cabin door. Review of the weight and balance information revealed that the airplane was loaded about 500 lbs above maximum gross takeoff weight.